In a surreal blend of animation and live-action, a World War II veteran named Frank Harris finds himself amidst a bizarre and fantastical universe called "Cool World" after surviving a tragic accident. This parallel dimension is populated by cartoonish characters, including Holli Would, a seductive and manipulative femme fatale. Holli, a nightclub singer, has an insatiable desire to transform into a real human and escape the confines of her animated existence. Years later, Jack Deebs, a comic book artist, mysteriously enters Cool World after being released from prison. Jack's comic series happens to chronicle the world he finds himself in, making his arrival puzzling yet significant.

Frank, now a detective, resides in Cool World to maintain a delicate balance between it and the real world, knowing that humans and "doodles" must never intermingle. Despite Frank's warnings, Jack becomes enamored with Holli, who tempts him with promises of forbidden desires. As Jack and Holli's dangerous flirtation threatens to merge Cool World and reality, tensions rise, bringing unpredictable chaos to both universes. The narrative unfolds through an exploration of temptation, identity, and the blurred lines between fantasy and reality, as Jack struggles to regain control over his fate while navigating the treacherous landscape of Cool World.