The plot centers around the life of Jackson Pollock, an American painter who becomes a leading figure in the abstract expressionist movement. At the beginning of his career, Pollock struggles with his art, battling his inner demons and the skepticism of the art world. His revolutionary technique of pouring or splashing liquid household paint onto a horizontal surface, enabling him to view and paint his canvases from all angles, propels him into the limelight. Despite his innovative approach and growing recognition, Pollock's life is marred by alcoholism and a volatile temper, which complicates his relationships and professional achievements.

Set primarily in the 1940s and 1950s, the narrative delves into Pollock's tumultuous relationship with fellow artist Lee Krasner, who becomes not only his wife but also his staunchest advocate. Krasner's influence is pivotal in Pollock's development as an artist, pushing him toward greater experiments in his art and eventually helping him to achieve fame. However, as Pollock's fame grows, so do his personal struggles. The pressures of success and his battle with addiction lead to an increasingly chaotic life. This period of his life is a profound exploration of the sacrifices and challenges faced by those who devote themselves to their art, highlighting the fine line between genius and self-destruction.