A centuries-old vampire named Lestat awakens from decades of slumber and is drawn to the modern world by the sound of heavy metal music. Fascinated by its defiant and rebellious nature, Lestat decides to reinvent himself as a rock star, using his supernatural abilities to captivate audiences worldwide. His music, imbued with cryptic references to his vampiric existence, draws the attention of both humans and the vampire community, unsettling the ancient covens who fear exposure. Among his followers is a mortal researcher named Jesse, who has a deep fascination with vampire lore and is part of a secretive group that studies the undead. Her curiosity about Lestat and his origins leads her into a dangerous exploration of the vampire underworld.

As Lestat's fame grows, his unorthodox behavior attracts the attention of Akasha, the first vampire and the eponymous queen. Enraptured by his audacity and power, Akasha awakens from her millennia-long slumber with a sinister agenda. Enthralled by the allure of his art, she offers Lestat unimaginable power and a place by her side to rule over a new world order. Meanwhile, Jesse's pursuit to uncover the mysteries surrounding Lestat places her in grave danger, as she delves deeper into a world fraught with ancient rivalries and deadly secrets. The collision of mortal curiosity and immortal ambition sets the stage for a climactic confrontation that will decide the fate of both humans and vampires.