Frank Martin, a skilled driver known for his impeccable record in the delivery of sensitive cargo, is forced back into the world of high-stakes courier work by an environmentalist group. With a device strapped to his wrist that will detonate if he moves too far from his car, Frank's newest job is to transport Valentina, the kidnapped daughter of a Ukrainian government official. Along the journey, Frank must abide by the unyielding rules set by the malign mastermind behind the scheme, who monitors their every move.

As Frank and Valentina travel across Europe, their path is fraught with obstacles set by those intent on preventing the transport's success. Frank uses his exceptional driving skills and resourcefulness to contend with the relentless perils thrown their way. Throughout the trip, a bond begins to develop between Frank and Valentina, giving Frank an added personal stake in fulfilling the mission and protecting his charge against the increasing dangers that surround them.