Two years after the events in Bangkok, the Wolfpack is at a crossroads. Alan, the group's wildcard, is off his ADHD medication and exhibiting increasingly erratic behavior. Following a personal crisis and a wild incident involving a giraffe on a freeway, his friends and family stage an intervention. They decide that it's time for Alan to seek professional help. As the gang, which includes Phil, Stu, and Doug, bands together to support Alan, they plan a road trip to Arizona for Alan's treatment at a mental health facility. Unbeknownst to them, their past misadventures are about to catch up with them in an unexpected way.

En route to Arizona, the Wolfpack is intercepted by a mob boss and his henchmen. The mob boss demands that the Wolfpack helps him find Mr. Chow, a flamboyant criminal who has stolen $21 million in gold from him. Chow has recently escaped from a Thai prison and has contacted Alan, the only link the mob has to locating Chow. The Wolfpack is coerced into this mad chase, with Doug being held hostage as collateral, leaving the remaining three no choice but to track down the unpredictable Chow. Their journey takes them from Tijuana, Mexico, to the glitzy streets of Las Vegas, where old memories resurface and new troubles await. They must navigate through a series of dangerous and comical ordeals in a bid to set things right, all while trying to stay out of harm's way themselves.