In three parallel narratives, each separated by centuries, a man grapples with mortality and eternal love. The first story unfolds in the 16th century, where a Spanish conquistador, Tomas, embarks on a quest through the Mayan jungles for the Tree of Life at the behest of Queen Isabella of Spain. She believes that the Tree's sap grants eternal life and hopes to ensure the Christianization of all the peoples of the world by securing it. The journey is perilous, filled with danger and driven by the promise of eternal love and salvation.

In the present day, a scientist named Tommy is desperately trying to find a cure for cancer that is slowly killing his wife, Izzi. She is also a writer, working on a story about that same conquistador and his search for the Tree of Life, a tale she is unable to finish due to her illness. As she weakens, she asks Tommy to complete the story for her. Struggling to accept the impending loss of his wife, Tommy throws himself into his work, becoming increasingly obsessed with finding a way to conquer death and save Izzi, leading him to discoveries that blur the lines between science, spirituality, and love.