In a quaint 19th-century English village, an eccentric veterinarian named Doctor John Dolittle discovers he possesses the extraordinary ability to communicate with animals in their own languages. He lives with his anthropomorphic animal companions, including Polynesia the parrot and Chee-Chee the chimpanzee. Initially dismissed as a madman by the townsfolk, Dolittle becomes renowned for his unique skill. Urged by Polynesia, Dolittle sets off on a fantastical voyage to find a legendary creature known as the Great Pink Sea Snail. He is joined by his loyal friends, Matthew Mugg, a dabbling Irishman, and Tommy Stubbins, a young boy eager to learn from the doctor. Together, they face various challenges and adventures along the way.

Throughout their journey, Dolittle and his companions encounter an array of colorful characters and exotic animals, allowing Dolittle to utilize his gift in remarkable ways. They traverse perilous landscapes, cross paths with pirates, and navigate uncharted territories in pursuit of their elusive goal. Their voyage through land and sea tests their resilience and determination, blending moments of suspense, comedy, and heartwarming exchanges. As their quest grows more intricate and perilous, the unique bond between man and animal remains at the heart of the adventure.