Jeffrey Franken, a New Jersey suburbanite and amateur scientist, is left devastated after a freak lawnmower accident dismembers his fiancée Elizabeth. In a desperate attempt to bring her back to life, Jeffrey concocts a plan to piece her together using parts from various women. He comes up with the idea of using the bodies of sex workers, viewing them as the most viable options for his gruesome patchwork project. Fueled by a bizarre blend of love and madness, Jeffrey creates a highly dangerous form of "super-crack" to assist in his mission to procure the necessary parts.

Using his invention, Jeffrey heads to Manhattan and lures a group of prostitutes with promises of money and drugs. A chain of horrific events ensues, leading to a chaotic and darkly comedic night. Jeffrey manages to collect the dismembered parts and returns to his lab to commence the reanimation process. He sews the parts together and, using a blend of science and electricity, attempts to revive Elizabeth. What follows is a surreal and grotesque confrontation with the unforeseen consequences of tampering with life and death.