A small-time pot dealer named David Clark finds himself in a major dilemma when some local punks steal his money and stash, leaving him in serious debt to his supplier, Brad Gurdlinger. In order to settle the score, David is coerced into smuggling a "smidge" of marijuana from Mexico into the United States. Realizing that a lone traveler is sure to raise suspicions at the border, David devises a plan to masquerade as a wholesome, all-American family on vacation, hoping to slip by the authorities unnoticed.

To create his fake family, the "Millers," David recruits a stripper named Rose to pose as his wife, a homeless teenager named Casey to be their pseudo daughter, and his nerdy neighbor Kenny to play the role of their son. With a shiny RV as their vehicle, the newly formed "family" sets off on a road trip that will test the limits of their makeshift domesticity. Their journey is fraught with unexpected challenges and comedic mishaps as they attempt to fulfill their mission and deliver the drugs, all while maintaining their suburban family facade.