In a secluded mansion, a brilliant but unorthodox plastic surgeon named Robert Ledgard has created an advanced artificial skin that is resistant to burns and insect bites. His inspiration for this invention is rooted in personal tragedy: his wife was severely burned in a car accident, and she later succumbed to her injuries. Now, Robert obsessively strives to perfect his creation, conducting secret experiments on a mysterious and beautiful woman named Vera, who is confined within his home. Vera's presence in the mansion is shrouded in secrecy, as she lives under tight surveillance and in luxurious, prison-like conditions.

As the story unravels through a series of flashbacks and present-day events, details about Vera's past, Robert's twisted motivations, and the true nature of their relationship gradually come to light. The film delves into themes of identity, revenge, and obsession, exploring the moral and ethical boundaries of medical science. The disturbing and psychological intensity builds as each revelation leads to the inevitable confrontation, forcing a reexamination of the personas and lives entangled in Robert's quest for perfection.