Seven years after the destruction of Raccoon City, a zombie outbreak occurs at Harvardville Airport, bringing chaos and a deadly virus back into the public eye. Leon S. Kennedy, now a U.S. government agent, is dispatched to deal with the situation alongside two other agents. They are soon joined by Claire Redfield, a survivor of the Raccoon City incident, who is now working for a non-profit organization dedicated to helping victims of biological weapons. The outbreak at the airport serves as a grim reminder of the potential for bioterrorism to cause mass casualties and the persistent threat of the Umbrella Corporation's viral legacy.

As they navigate the chaos of the airport, the group discovers that the outbreak is not a random incident but a terrorist attack orchestrated by a sinister figure seeking vengeance. This individual has a deep personal grudge and intends to use the virus for catastrophic retribution. The airport incident quickly escalates into a larger conspiracy, revealing a threat that could unleash a global pandemic. Struggling against time, Leon and Claire must uncover the terrorist's motives and stop them before they can execute their plan, highlighting the continuing struggle against bio-organic weapons and the shadowy entities that seek to exploit them for power and revenge.