The film intricately explores the life and groundbreaking work of theoretical physicist Stephen Hawking. It delves into his early years plagued by physical limitations due to ALS, a degenerative disease he was diagnosed with at a young age. Despite his condition, Hawking's brilliance and curiosity about the universe remain undiminished. The narrative interweaves his personal struggles and achievements, highlighting how he overcame significant challenges to contribute valuable insights to the field of cosmology and theoretical physics.

The documentary also provides a detailed look at Hawking's scientific theories, especially his work related to black holes and the origin of the universe. Through interviews with family members, friends, and colleagues, as well as dramatized scenes and Hawking’s own words, the viewer gains an understanding of both the man and his profound intellectual contributions. The film balances biographical elements with explorations of complex scientific ideas, making Hawking's research accessible and engaging to a broad audience.