Three talented women work for a mysterious boss named Charlie, who communicates with them through speakerphone. They are highly trained in a variety of physical skills, including martial arts and espionage, and work as private investigators for Charlie's detective agency. The team consists of the athletic and bubbly Natalie, the tough and street-smart Dylan, and the sophisticated and intelligent Alex. The trio is assisted by Charlie's liaison, Bosley, who provides them with missions and support.

When a brilliant software entrepreneur, Eric Knox, is kidnapped, his company suspects a rival mogul, Roger Corwin, of being behind the abduction. The women are tasked with finding Knox and uncovering the truth behind his disappearance. Their investigation leads them to infiltrate a corporate party, engage in high-speed chases, and confront formidable henchmen. As they delve deeper into the mystery, the three agents use their diverse abilities to unravel a plot that threatens individual privacy and security on a global scale.