In Pittsburgh, Marie, a vampire with a conscience, strives to control her bloodlust by only feeding on criminals. One night, she targets Sal "The Shark" Macelli, a notorious mob boss. However, her feeding ritual is interrupted and Macelli turns into a vampire himself. As he starts converting members of his gang into vampires to bolster his criminal empire, Marie realizes her mistake and feels compelled to stop him. Meanwhile, undercover cop Joe Gennaro is trying to bring down Macelli’s mob through the traditional means of law enforcement. His path crosses with Marie when he discovers her true nature and intentions.

Realizing they have a common enemy in Macelli, Marie and Joe form an uneasy alliance. They must navigate the dangers posed by both a vampire mob and the legal system closing in on them. Marie is torn between her desire to remain hidden and her responsibility to clean up the mess she inadvertently created. As they chase Macelli through an increasingly perilous cityscape, Marie’s superhuman abilities clash with Joe’s need for lawful resolution. The tension mounts as they inch closer to confronting the menace that threatens to turn Pittsburgh into a vampire haven, leading to a climactic confrontation where forces of good and evil collide.