The story follows Lon Chaney, a talented vaudeville performer who rises to fame in the early 20th century with his incredible skill in makeup and acting, enabling him to transform himself into a variety of characters. Battling personal challenges, including a tumultuous relationship with his first wife, Cleva, and raising a deaf-mute son, Chaney’s dedication to his craft is unwavering. His ability to evoke powerful emotions through his roles, despite personal tragedies, earns him widespread acclaim.

As Chaney moves from stage to silent films, his reputation as "The Man of a Thousand Faces" solidifies. His groundbreaking work in horror films and character roles garners further success, even as he faces ongoing personal and professional struggles. Overcoming challenges that test his resilience and commitment to his craft, his legacy as a pioneering figure in the world of acting endures beyond the screen.