In the late 19th century, famed gunman Wild Bill Hickok is haunted by recurring nightmares of a massive white buffalo. Tormented by these visions, he embarks on a lone quest to hunt down the creature and put an end to his torment. As he travels through the American frontier, Hickok adopts a new identity to keep a low profile and encounters an old comrade, Charlie Zane. Amidst breathtaking snowy landscapes, the duo encounters hostile forces and wary townsfolk, reflecting the harsh realities of the Wild West. Hickok's journey is not just a physical pursuit but also a reflection of facing inner demons and confronting past regrets.

Meanwhile, on a converging path, Lakota warrior Crazy Horse seeks the same mythical beast. The white buffalo has ravaged his people, leading him to embark on a spiritual mission to kill it for vengeance and redemption. As chance brings Hickok and Crazy Horse together, they realize their fates are intertwined. Each man, driven by personal motives yet linked by a common goal, must navigate the treacherous terrain and their complex backgrounds. As they confront various trials and enemies along their path, they must consider whether they will work together against their powerful and elusive prey, not fully realizing how this perilous chase will test their courage and shape their destinies.