Ten years after the events that led to the proliferation of monstrous creatures on Earth, the Infected Zones have now spread worldwide. In the Middle East, another insurgency has risen up alongside the monstrous threat, complicating military efforts to contain both the creatures and the human conflict. Amidst this backdrop, the film follows a group of American soldiers tasked with a mission deep into the heart of the Infected Zone. As they journey through the dangerous landscape, their objectives and loyalties are put to the test, revealing the harsh realities of war, both against human and non-human adversaries.

The central focus is on Michael, a seasoned soldier, and his new recruit, Frankie. The dynamic between them explores themes of brotherhood, loss, and the disillusionment with the heroic ideals of warfare. Their relationship deepens as they encounter a series of harrowing situations that challenge their perceptions of the enemy and the nature of the conflict itself. Encounters with the local populace add layers to their understanding, blurring the lines between friend and foe, and emphasizing the widespread impact of the ongoing battles on ordinary lives. The harsh desert landscape and the lurking, often unseen monsters serve as a constant reminder of the precariousness of their mission and the ever-present threat of sudden violence.