John Constantine, a seasoned demon hunter and master of the occult, is living a life burdened by his past sins. Despite his attempts to maintain a semblance of normalcy, his reputation for dealing with the supernatural precedes him. When his old friend Chas Chandler comes to him for help, Constantine is reluctantly thrust into a new mystery. Chas's daughter Trish is inexplicably in a supernatural comatose state, and all conventional methods of waking her have failed. Constantine's investigation leads him to realize that this is no ordinary ailment but rather the work of dark magic.

To save Trish's soul, Constantine must delve deep into the underbelly of the supernatural realm. His journey takes him across various dimensions filled with demons and otherworldly beings. With his extensive knowledge of the dark arts, Constantine pieces together that there are high stakes involving powerful forces vying for control. Unraveling the complex weave of spells and dark magic, he must confront his own inner demons along the way, challenging his abilities and resolve.