Marley Corbett is a carefree, fun-loving woman who works at a successful advertising firm in New Orleans. Despite her lighthearted approach to life and reluctance to settle down, her world takes a serious turn when she is diagnosed with terminal colon cancer. During a particularly whimsical consultation, she meets Dr. Julian Goldstein, her charming and compassionate doctor, with whom she starts to form an unexpected bond. As Marley grapples with her diagnosis, she initially continues to avoid confronting her fears and refuses to tell her friends and family the harsh reality of her condition. Nonetheless, through humor, warmth, and occasional denial, Marley gradually begins to reassess her outlook on life and relationships.

She rekindles her relationships, starting with her estranged parents, Beverly and Jack. As she navigates the complexities of facing her mortality, Marley opens herself up to love in a way she never thought possible, especially as her connection with Julian deepens. With encouragement from her loyal friends, Renee, Sarah, and Peter, Marley learns to accept the need for support, embracing the sincerity of those around her. Her journey takes her from managing her illness with a feisty spirit to confronting deeper, often hidden, emotional truths.