Eugene and Tucker are childhood best friends leading contrasting lives; Eugene is the cautious and principled one, while Tucker is impulsive and wild. As Eugene prepares for a big night to lose his virginity to his high school sweetheart, Cindy, a mishap leads to him falling down a flight of stairs and slipping into a coma, which lasts for four years. Upon awakening, Eugene discovers that life has changed drastically. Tucker fills him in on the shocking news that Cindy, who he thought would be waiting for him, has become a Playboy centerfold during his prolonged unconsciousness.

Determined to reunite with Cindy and make sense of the chaotic turn his life has taken, Eugene reluctantly teams up with Tucker on a cross-country road trip to attend a party at the Playboy Mansion. Along the way, the duo faces a series of absurd and increasingly wild escapades, from run-ins with eccentric characters to outrageous roadblocks. As they delve deeper into their bizarre journey, Eugene and Tucker’s friendship is tested, and they learn to confront their own insecurities and misconceptions. This thrilling adventure propels Eugene on a path of self-discovery and reevaluation of what truly matters in his life.