Peter LaFleur owns Average Joe's Gymnasium, a small, decrepit fitness center with an eccentric clientele. Facing foreclosure, Peter learns that his gym will be bought out by White Goodman, the egotistical owner of Globo Gym, a gleaming sports club empire across the street. In a desperate bid to save his gym, Peter and his ragtag group of gym members decide to enter a dodgeball tournament in Las Vegas. The tournament promises a cash prize large enough to save Average Joe's from bankruptcy and fend off Goodman's takeover.

Forming a dodgeball team, Peter and his friends—Justin, a teenager obsessed with impressing his crush; Gordon, a meek man obsessed with obscure sports; Owen, a simple-minded enthusiast; and Steve, a man who thinks he is a pirate—set out to learn the game under the tutelage of Patches O'Houlihan, a dodgeball legend turned wheelchair-bound recluse. Despite their lack of skill, the team's spirit and camaraderie shine as they face increasingly tough and bizarre teams in the tournament. Across the court, Goodman forms his own elite dodgeball team, intent on crushing Average Joe's and securing his corporate expansion. As the competition heats up, both teams are determined to win, setting the stage for a showdown filled with humor, heart, and flying dodgeballs.