Gonzo, experiencing a personal identity crisis, begins receiving mysterious messages that suggest he is not alone in the universe. Struggling with his feelings of isolation and a deep desire to find out where he truly belongs, Gonzo becomes convinced that his family is from outer space. He broadcasts his belief to the world, which attracts the attention of a government agency eager to unlock the secrets of Gonzo’s extraterrestrial connections. As Gonzo's friends rally to support him, they are swept into a series of comedic and adventurous escapades. Led by Kermit, the Muppets team embarks on a quest to uncover the truth about Gonzo's origins while evading capture by the zealous government agent, Ed Singer.

The Muppets' journey is filled with hilariously unexpected encounters and challenges that test their loyalty and friendship. As they dodge traps and outsmart their pursuers, the group learns more about Gonzo's enigmatic past. Along the way, the Muppets' trademark humor and unwavering camaraderie shine as they work together to help Gonzo achieve his dream of making contact with his alien kin. The story is a heartfelt exploration of identity, belonging, and the power of friendship against overwhelming odds. With time running out, the Muppets face their biggest challenge yet in a climactic showdown that will determine Gonzo’s fate and solidify the bond between these unlikely heroes.