A mysterious comet passes by Earth, causing electronic devices and machines to come to life and turn against humanity. A group of people, including diner cook Bill Robinson, truck stop owner Bubba Hendershot, and hitchhiker Brett, find themselves trapped in a North Carolina truck stop when the trucks outside become homicidal. They quickly realize that the trucks have developed a sinister kind of intelligence and are bent on killing anyone who tries to leave. The survivors must band together to find a way out while contending with the increasingly aggressive vehicles.

As fear and desperation grow, the group devises a plan to escape the truck stop and hopefully survive the chaos wrought by the self-aware machines. They scavenge for resources and engage in dangerous maneuvers to stay alive, all while the trucks relentlessly hunt them down. With time running out and their options dwindling, the survivors must confront the terrifying reality that their only chances of survival lie in their ability to outsmart the deadly machines that have taken control.