A legendary feline outlaw, Puss in Boots, discovers that his passion for peril and disregard for safety have taken their toll: he has burned through eight of his nine lives, though he has lived them with bravado. Shaken by the realization that he is down to his last life, Puss embarks on an epic journey to find the mythical Last Wish and restore his nine lives. As he sets out on his quest, he tries to retire from his adventurous ways, but finds that old habits die hard, and living a quiet life is more challenging than he expected.

Along the way, Puss reunites with an old flame, Kitty Softpaws, who is just as sharp and independent as ever. The duo encounters a new ally, Perrito, a chatty and cheerful mutt who helps them on their journey. Together, they face numerous obstacles, including a relentless bounty hunter who is set on capturing Puss, and a host of other fairytale creatures with their own dark and devious intentions. While searching for the Last Wish, Puss and his companions must navigate their way through dark forests and treacherous terrains filled with both danger and opportunity, discovering that the biggest obstacle to their quest might just be Puss’s own inner conflict between his fear of mortality and his insatiable thirst for adventure.