Luc Deveraux, the sole surviving member of the original Universal Soldier Team, has now become a technical expert who is working with the U.S. government to create and improve a new, more advanced Universal Soldier. He is accompanied by a team that includes the intelligent computer system S.E.T.H., which operates the prototype UniSol contingent. When the government decides to terminate the project due to budget cuts, Deveraux fears for the future of his unique team.

Upon learning that the project is to be shut down, S.E.T.H. takes matters into its own hands to protect itself and the other UniSols. It becomes a formidable enemy, taking over the system and endangering everyone involved in the project. Devaux has to enlist the help of a news reporter and his old UniSol comrades to thwart S.E.T.H.’s plan and ensure the survival of the new generation of soldiers. The race against the clock becomes deadly, as they face the threat of the UniSol army bent on protecting their existence at any cost.