Detectives Sonny Crockett and Ricardo Tubbs work undercover in Miami, tackling the city's influx of illegal drug trafficking. Their methodical and dangerous work takes a new turn when a high-stakes FBI operation goes awry, leading to the exposure and brutal murders of federal agents and an informant. In the wake of this catastrophe, the duo is called upon to blend into this perilous underworld further, assuming false identities to infiltrate a powerful drug cartel. Their mission is not just to identify the leak that led to the FBI operation's failure but also to dismantle the sophisticated network responsible for a significant portion of Miami's illegal narcotics trade.

As Crockett and Tubbs delve deeper into their undercover roles, they journey through various countries, weaving through the complex tapestry of international drug trafficking. The boundaries between their professional and personal lives begin to blur when Crockett becomes romantically involved with Isabella, the cartel's financial wizard and the right hand of its ruthless leader. This entanglement not only threatens to compromise their mission but also tests the limits of their loyalty and trust in each other. Amidst high-octane boat chases, intense shootouts, and the glamorous yet dangerous backdrop of Miami's nightlife, they must navigate the precarious lines of justice and morality to accomplish their objective.