Private detective Nick Charles and his wife Nora attend a charity benefit aboard a gambling ship owned by Phil Brant. During the event, a prominent bandleader named Tommy Drake is murdered, and suspicion falls on several attendees, including Brant. The Charles couple, along with their dog Asta, are soon drawn into a complex investigation involving the New York jazz scene's eccentric personalities and shady criminal elements. Nick interviews various musicians and suspects, including singer Fran Page and musician Buddy Hollis, uncovering personal vendettas and hidden motives that complicate the case.

As the investigation deepens, Nick pieces together clues that involve jealousy, deceit, and betrayal within the music world. Although Nick tries to steer clear of danger, his curiosity leads him into risky encounters with potential suspects. Meanwhile, Nora provides insight and support in her clever and charming manner. The couple's witty banter helps them navigate tense situations, even as the danger escalates. As they draw closer to unraveling the identity of the real murderer, they find themselves in a perilous scenario that tests their detective skills and quick thinking. Throughout the twisting investigation, both the vibrant nightlife of New York and a cast of colorful characters leave indelible marks on the unfolding mystery.