During World War II, a scrawny volunteer named Steve Rogers undergoes an experimental procedure to become a super-soldier. Abandoned behind enemy lines, he transforms into the heroic Captain America. His primary mission is to stop the Red Skull, a fascist operative and product of his own super-soldier experiment, who now has plans for global devastation. Captain America’s initial encounter with the Red Skull ends abruptly, as he is frozen in ice during a climactic battle.

Decades later, he is discovered and revived in the present day. Disoriented by the modern world but determined to complete his mission, Captain America learns that the Red Skull has survived and adapted his plans to contemporary threats. Seeking alliances and reconciling with his displaced sense of time, he races against the clock to thwart the Red Skull's latest scheme, confronting both his old foe and new dangers along the way.