In the grim continuation of a visceral saga, the story follows FBI Agent Strahm, who, having narrowly escaped one of Jigsaw's traps, is now hot on the trail of Detective Hoffman. With the notorious Jigsaw killer, John Kramer, now deceased, Hoffman emerges as the unchallenged successor to Jigsaw's legacy of twisted justice and brutal tests of survival. Strahm's obsession with uncovering the truth sees him delving deeper into the maze of horrors and machinations that define Jigsaw's world. Meanwhile, Hoffman meticulously crafts his next series of diabolical games to carry on the work of his mentor, ensuring his deadly puzzles remain a step ahead of the authorities.

Simultaneously, another game is set into motion as a group of five individuals find themselves trapped and forced to navigate a series of lethal trials. Bound by their choices and actions from the past, each trap is designed to test their will to survive and demands they make unimaginable sacrifices to proceed. As the group's dynamics shift under the pressure of their dire circumstances, their instincts for self-preservation come to the forefront, highlighting the core of Jigsaw’s philosophy—that of valuing life through the face of death. With the clock ticking, they must decipher the connections that bind them and confront the consequences of their actions if they are to escape their gruesome fates.