Steve and Dennis, two paramedic partners and long-time friends in New Orleans, begin to encounter a series of bizarre and gruesome medical cases linked to a new, mysterious designer drug. As the cases intensify, Steve, who is dealing with his own personal issues including a terminal illness, discovers that the drug, when taken, allows its users to travel through time. Driven by a sense of duty and curiosity, Steve delves deeper into the nature of the drug to understand its effects and implications, especially after Dennis's daughter, Brianna, goes missing after allegedly taking it.

Determined to find Brianna and bring her back, Steve starts experimenting with the drug on himself. He begins to experience disorienting and dangerous trips to various points in the past, each journey revealing more about the unpredictable nature of time travel and the perilous situations the time periods hold. With time running precious and dangers mounting, Steve must navigate through treacherous moments in history and piece together clues to save his friend's daughter while battling his own fears and mortality. The story's tension builds as the boundaries between past and present blur, leading to a gripping culmination.