Coffin "Coffy" Coffin works as a nurse but moonlights as a vigilante determined to take down the drug dealers responsible for hooking her younger sister on heroin. Fueled by anger and a desire for vengeance, she goes undercover and starts a one-woman war against drug kingpins, using her street smarts and bold tactics. Her mission leads her to confront various pimps, pushers, and corrupt officials in the seedy underbelly of the city. Each encounter brings her closer to the top of the drug ring, revealing a web of deceit and corruption that permeates the highest levels of power.

As she navigates this dangerous world, Coffy faces life-threatening situations and moral dilemmas that challenge her notions of justice and revenge. Her relentless pursuit brings her into contact with old friends and introduces new enemies, exposing the complexities of loyalty and trust. Infiltrating deeper into the criminal network, she uncovers some shocking truths that test her resolve and reshape her understanding of the true cost of her vigilantism.