A brilliant but morally ambiguous surgeon, Baron Victor Frankenstein, continues his experiments to create life, even after facing rejection and imprisonment. He adopts the pseudonym Dr. Carl Victor and begins working at an insane asylum, whose director allows him to conduct his macabre surgeries on patients. Here he meets Simon Helder, a young doctor fascinated by Frankenstein's work, who has been committed to the asylum due to his similar interest in reanimation. Dr. Victor takes Helder under his wing, and together they pursue the Baron’s ultimate quest: to create a new, more perfect human being. They select their body parts from deceased inmates and employ unconventional methods to animate the corpse.

As the ambitious project progresses, which involves intricate surgical procedures and dangerous experimentation, tensions rise within the asylum. Sarah, a mute assistant who can communicate only through gestures, becomes deeply involved in their work and begins to develop feelings for Helder. They succeed in creating a monstrous yet highly intelligent creature, but the experiment brings unforeseen consequences. Staff and patients alike begin to notice peculiar changes that hint at the darker side of the creation. Before long, the ambition and moral compromises of Frankenstein threaten to lead to disastrous outcomes that could pose a severe danger to everyone within the asylum.