Rose, desperate to find a cure for her adopted daughter Sharon's terrifying nightmares and sleepwalking episodes which often involve the mysterious town of Silent Hill, decides to take Sharon there, hoping to find answers. Ignoring the warnings of her husband, Rose drives Sharon to the ghostly, fog-enshrouded town of Silent Hill, West Virginia - a place that seems to exist outside the bounds of reality and is reputed to be haunted, cursed, or both. Their arrival triggers a series of bizarre events, beginning with a car crash that knocks Rose unconscious. When she awakens, she finds herself in a desolate, ash-covered version of the town, and Sharon is missing.

Determined to find her daughter, Rose begins a frantic search through the eerie town, where she encounters twisted creatures and remnants of the town's tortured past. As Rose delves deeper into Silent Hill's secrets, she crosses paths with Cybil, a police officer who was drawn into the town's strange realm while searching for her. Together, they try to navigate their way through the town's dangerous alternate dimensions, seeking clues to Sharon's whereabouts while uncovering the dark history of Silent Hill, which involves a cult, a devastating fire, and a series of events that led to the town's current state. As Rose gets closer to the truth, she realizes that rescuing Sharon might require facing horrors beyond her darkest fears.