Gerry, a down-on-his-luck gambler struggling with mounting debts, encounters the charismatic Curtis at a poker table in Dubuque, Iowa. Sensing Curtis's incredible luck and charm, Gerry convinces him to join a road trip down the Mississippi River, hoping to change his fortunes. The duo set out on a journey aimed at high-stakes card games and gambling opportunities at various casinos along the river. As they navigate through a series of wins and losses, their personalities clash and bond, revealing vulnerabilities and dreams that drive their compulsion for gambling.

The trip grows increasingly intense as they venture deeper into the South, facing personal demons and testing their limits. They encounter a range of characters who expose the stark realities of the gambling world and their lives. Gerry's desperation for a big win and Curtis's carefree demeanor create a volatile mix. Underneath their quest lies an exploration of friendship, trust, and redemption. Each gamble becomes more than a chance for money but a pivotal moment that defines their course, leading the story to an uncertain future built on hope and risky bets.