Mitch Weaver is a luckless, unemployed man who prides himself on getting revenge against those who wrong him. His best friend, Sam McKenna, is similarly hapless. When Sam's father, Pops, falls seriously ill and needs a costly heart transplant, the duo decides to open a revenge-for-hire business to raise the necessary funds. Their unorthodox business proves surprisingly successful as they tackle various targets, including cheating spouses and unscrupulous businessmen, employing hilariously outrageous and often destructive methods.

As their business grows, Mitch and Sam face escalating challenges and increasingly complex revenge jobs. Their success attracts both admirers and adversaries, leading them to take on their most ambitious project yet. While dealing with their growing demand, they must also navigate personal struggles and maintain their friendship, all while striving to gather enough money to save Pops. The story takes several unexpected turns as Mitch and Sam's creative tactics garner both results and chaos, leading to an unpredictable series of events that test their ingenuity and resolve.