In the small town of Gunnison, Colorado, the aftermath of a battle between two extraterrestrial species crash-lands on Earth when a Predator spaceship crashes, unleashing a deadly Alien life form. The townspeople find themselves caught in the crossfire of an ancient conflict between the Predator hunters and the Alien creatures, as a lone Predator arrives with a mission to destroy any traces of the Alien presence and prevent their spread on Earth. Unaware of the extraterrestrial nature of their predicament, residents face an escalating horror that threatens their very survival.

As the Alien infestation grows and the conflict intensifies, the Predator uses its advanced technology and hunting skills to track and eliminate the Aliens while causing collateral damage. Meanwhile, a group of survivors, including a soldier, a sheriff, and other locals, find themselves forced to rely on each other and any means at their disposal to defend their town. They must navigate the chaos, understanding that they are in the midst of a war that has been brought to their doorstep, with little chance of outside help. The merging of two lethal extraterrestrial species on Earth sets the stage for a climactic showdown, with the humans caught in the middle, struggling to avoid becoming collateral damage or hosts for the Aliens.