In a time long past, the last of the free tribes in ancient times are on the edge of annihilation, facing the armies of an oppressive tyrant known as Memnon. This despot seeks to conquer and rule the known world with the aid of prophecies provided by a sorceress who can predict the outcomes of battles, granting him invincibility. As Memnon's forces decimate opposition, the few remaining tribal leaders decide on a desperate plan – they hire Mathayus, an elite assassin and the last of the Akkadians, to eliminate the sorceress and destabilize Memnon's grip on power.

Mathayus embarks on his mission, infiltrating Memnon's stronghold, but his plan takes an unexpected turn and he finds himself the target of the tyrant's wrath. Narrowly escaping with his life, Mathayus kidnaps the sorceress. As they flee through the desert, pursued by Memnon's henchmen, they encounter a range of challenges and adversaries but also unexpected allies. The growing bond between Mathayus and the sorceress complicates the journey, leading Mathayus to question his motives and purpose.