After his release from prison, Jake reunites with his brother Elwood, and they visit the Catholic orphanage where they were raised. They learn the institution will be closed unless $5,000 in property taxes is paid. The brothers decide to reform their rhythm and blues band to raise the needed money. They set out to reassemble their former bandmates, who have scattered since the group's breakup, in order to stage a fundraising concert. As they track down each member, they encounter a series of comedic obstacles and a mounting number of people with reasons to chase them, including neo-Nazis, the police, and a mystery woman with lethal weaponry.

While the brothers' band comes together, their escapades attract more attention, and the police intensify their pursuit. They must navigate their way through country and western bars, dodge vengeful ex-bandmates, and negotiate with skeptical music agents to secure a venue for their performance. The deadline to save the orphanage looms as their chaotic journey gathers an eclectic mix of characters, each contributing to the turbulent ride towards their goal. Their commitment to the mission is unwavering, even as the chase escalates into a frenetic and law-defying dash against time.