In the year 2047, a distress signal from the starship Event Horizon, a vessel that disappeared during its maiden voyage and has been missing for seven years, is detected coming from the proximity of Neptune. The spaceship Lewis and Clark is dispatched on a rescue mission led by Captain Miller, with the objective of investigating and salvaging the Event Horizon. Accompanying them on this mission is Dr. William Weir, the ship's designer, who reveals that the Event Horizon was built to test an experimental gravity drive capable of creating an artificial black hole, intended as a means for faster-than-light travel.

Upon arrival at the derelict Event Horizon, the crew of the Lewis and Clark board the vessel and begin to experience unsettling phenomena. As they delve deeper into the ship, they discover evidence of a catastrophic event and are confronted with horrific visions related to their individual fears and past traumas. Tensions rise as the crew starts to question the nature of the ship's disappearance and the true function of the gravity drive, which appears to have had a profound and possibly malevolent influence on the Event Horizon. Meanwhile, Dr. Weir becomes increasingly obsessed with the ship and the technology he created, driving a wedge between him and the rest of the rescue team as they seek to unravel the mystery amidst growing paranoia and dread.