Retired CIA agent Frank Moses reunites with his unlikely team of elite operatives for a global quest to track down a portable nuclear device. After the events of their last mission, Frank lives a quiet life with his girlfriend Sarah, but his peaceful retirement is disrupted when his old friend Marvin appears with news that they've been labeled as participants in a top-secret Cold War project known as Operation Nightshade, which aimed to smuggle a nuclear weapon into Russia. When Marvin dies in a car explosion and Frank is interrogated by government agents, it becomes clear that the missing nuclear device is linked to them, and they must clear their names. Frank and Sarah, along with their old colleague Victoria, embark on an international journey to find the device, escaping assassins and dealing with contract killers sent by their adversaries.

The hunt leads them from the United States to Paris, London, and Moscow, confronting new foes and reuniting with old allies. They discover that they're up against a vast conspiracy that extends well beyond their initial predicament. As they dive deeper into the world of espionage, they encounter lethal foes at every turn, including ruthless hitmen and relentless terrorists. Throughout their mission, they have to rely on their cunning and skills to stay ahead of their pursuers and prevent a global catastrophe. The team navigates a maze of deadly traps with their usual humor and resourcefulness while dealing with the challenges of their personal lives intertwined with their professional ones.