In the first half, a psychotic stuntman moonlights as a serial killer using his "death proof" stunt car as his weapon of choice. He preys on young women, selecting those he encounters in bars to be his next victims. On one particular night, he sets his sights on a group of friends, engaging them with his charm before offering a ride in his car. Unbeknownst to them, the car is modified to be lethal to passengers while keeping the driver safe. His methodical approach and twisted sense of invulnerability lead him to pursue his deadly game under the guise of accidents.

The second half of the narrative shifts focus to another group of women, this time a trio on a break from working on a movie set. They are passionate about cars and stunts, showcasing a stark contrast to the victims introduced earlier. Their encounter with the stuntman leads to a high-stakes game of cat and mouse. As they become aware of his malicious intentions, they must use their wit and driving skills to survive. The story evolves into a tense thriller, highlighting themes of vengeance and empowerment, as the women band together to confront their assailant.