Two Miami detectives, Marcus Burnett and Mike Lowrey, are tasked with a high-stakes mission when a cache of heroin worth $100 million is stolen from the secure police vault. Burnett is a family man, while Lowrey is a suave bachelor, but they are united by their commitment to their work. The theft is an embarrassment for their department, and they are given five days to recover the drugs before the shutdown of the narcotics division. The case heats up when a murder leads to the sole witness, Julie Mott, who only trusts the absent Lowrey, having never met him.

Faced with the necessity of protecting their witness and solving the case, Burnett is forced to impersonate the bachelor Lowrey, disrupting both his personal and professional life. As the detectives dive deeper into the investigation, their partnership is put to the test. They navigate through the Miami underworld, full of car chases, explosions, and shootouts, all while maintaining their cover. Fueled by their desire to protect the city and their comedic banter, the duo seeks to retrieve the stolen drugs and bring down the mastermind behind the heist before their time runs out.