Former government operative Bryan Mills lives a relatively quiet life as he continues to support his daughter Kim and rebuild his relationship with his ex-wife, Lenore. His world shatters when he finds Lenore brutally murdered in his own home, and he becomes the primary suspect. Fleeing from the authorities, Mills uses his specialized skills to evade capture and simultaneously counteract the manhunt led by tenacious LAPD Inspector Frank Dotzler. Determined to clear his name, Mills digs deeper into the mystery, revealing that the murder was part of a larger conspiracy that threatens his family.

As he unravels the intricate web of deceit, Mills discovers powerful adversaries who will stop at nothing to see him behind bars or dead. He relies on his resourcefulness and contacts, including former colleagues, to stay ahead of his pursuers and protect Kim from further danger. While fighting off relentless attackers and piecing together clues, Mills must confront painful truths and make desperate choices. This leads to an intense showdown where the stakes are higher than ever before, forcing Mills to use every ounce of his training to ensure the safety of his loved ones and secure justice.