Herbert West, a scientist imprisoned for his previous experiments with reanimation, continues his work in secret while incarcerated. He collaborates with a young and ambitious doctor named Howard Phillips, recently assigned to the prison hospital, who is eager to explore West’s groundbreaking research. Together, they manage to reanimate dead tissue using a special serum developed by West. As their experiments progress, they discover a new element that can trap and restore lost human consciousness, leading them towards potentially altering the nature of life and death.

As reanimated creatures and serum-induced chaos increase within the prison walls, the ethical boundaries become blurrier. The consequences of tampering with life and death create intensified tensions among the prison’s staff and inmates. A string of terrifying events escalates, putting both the prison’s occupants and the doctors in jeopardy, as the limits of West’s serum and its horrifying effects are tested to the extreme.