In the late 19th century, a safari guide leads a group of ivory hunters through the wilderness of Southern Africa. Tensions rise when the hunters offend a local tribe by refusing to offer gifts of respect, leading to a brutal retaliatory attack. The tribe captures the men, subjecting them to cruel and fatal punishments, except for the guide, who is granted a chance at survival. Stripped of everything and given a brief head start, he is left to run for his life while being relentlessly pursued by the tribe's best warriors.

Against an unforgiving landscape, the guide taps into his survival skills, navigating dense jungles, arid savannas, and dangerous wildlife. Despite severe physical and mental exhaustion, he manages to stay one step ahead of his pursuers, utilizing wits and resilience. Encounters with hostile environments and internal struggles punctuate his harrowing escape. As he confronts both natural obstacles and threats from the determined hunters behind him, the primal battle between human endurance and the lethal persistence of his foes intensifies.