Several years after the demise of the Jurassic World theme park on Isla Nublar, the remaining dinosaurs face a new threat: the island's once dormant volcano has reawakened and is on the brink of erupting. Former park manager Claire Dearing has now become an advocate for dinosaur preservation, leading the Dinosaur Protection Group. She is contacted by Benjamin Lockwood, John Hammond's former partner in creating the original dinosaurs, who has a plan to rescue as many species as possible. With funding and resources from Lockwood's estate, Claire returns to the island, seeking the aid of Velociraptor trainer Owen Grady to locate Blue, the last surviving raptor he raised.

Claire and Owen reassemble a team and set out on the dangerous mission to the volatile island, racing against time to save the creatures before the eruption can wipe them out. Upon arrival, they discover that their rescue operation might not be as benevolent as it seemed. Hidden agendas from within Lockwood's organization surface, posing new ethical questions regarding the treatment and rights of the dinosaurs. The team must navigate a chaotic landscape filled with treacherous new breeds of dinosaurs and unravel the conspiracy that threatens the very existence of these ancient creatures.