Estranged best friends Harold and Kumar have drifted apart since their last adventure. Now leading different lives, Harold is a successful businessman with a beautiful house and family obligations, while Kumar's life remains chaotic and aimless. The plot kicks off when Kumar receives a mysterious package addressed to Harold, prompting him to visit Harold's home on Christmas Eve. During their encounter, a mishap involving Harold's prized Christmas tree sets off a series of chaotic events. Desperate to make things right before Harold's father-in-law arrives, the duo embarks on a wild journey through New York City to find a perfect replacement tree.

Along the way, they encounter old friends and new obstacles, including bizarre parties, dangerous mobsters, and unexpected reunions. The tension between Harold and Kumar gradually subsides as they rediscover their bond and reflect on the importance of their friendship. Their adventure is filled with both hilarious misunderstandings and touching moments that emphasize the themes of camaraderie and holiday spirit. As they race against time, they must navigate through their differences, all while facing increasingly outrageous and comical challenges.