Two friends, Jesse and Chester, wake up after a night of partying with no recollection of the previous evening, nor where they parked Jesse's car. Discovering a trail of clues left behind, they realize their amnesia-laden adventure is far from over. Amid their quest to find the missing vehicle, they encounter a slew of bizarre occurrences and characters, including their angry girlfriends demanding a special anniversary gift, a transsexual stripper with vital information, and a cult obsessed with a mystical device. The duo's misadventures lead them through a series of comedic and unexpected challenges as they try desperately to make sense of the confusing situation.

Their journey becomes even more complicated as they are inadvertently drawn into a cosmic puzzle involving alien beings who are also on a quest related to the whereabouts of the car. The friends must navigate through this peculiar and increasingly dangerous scenario, all while trying to piece together their lost night. The quest for the missing car becomes a wild adventure that tests their friendship and their wits, as they discover that the events of the forgotten night are significantly more important than they initially seemed. With each clue, they are pulled deeper into an unexpected world of mystery and intrigue that surpasses their wildest imaginations.