Amanda Waller reassembles the Suicide Squad—a group of incarcerated supervillains with nothing to lose—offering them clemency in exchange for completing covert, high-risk missions for the U.S. government. This time, the mission is deeply personal for Waller. She tasks the unpredictable ensemble, including Deadshot, Harley Quinn, Bronze Tiger, Captain Boomerang, Killer Frost, and Copperhead, with the retrieval of a mystical object so powerful that they're willing to risk their own lives to steal it. As they set out on their latest death-defying adventure, the squad must contend with the intense opposition from other nefarious figures who seek the object for their own sinister purposes.

The Suicide Squad battles through an onslaught of adversaries while dealing with their internal conflicts and clashing personalities. Trust is a rare commodity among the supervillains, and betrayal surfaces as they confront the true nature of the mission. The stakes are higher than ever, as it becomes clear that the mystical object they've been ordered to secure holds the key to an immeasurable power that could change the balance of their very existence. Hindered by their own treacherous inclinations and the external forces vying for control, the squad is forced to make tough decisions and take even tougher actions if they hope to succeed in their dangerous quest.