An immortal supervillain, Vandal Savage, gathers a team of villains inclusive of Bane, Cheetah, Metallo, Mirror Master, Ma'alefa'ak, and Star Sapphire, each with a grudge against a member of the Justice League. Savage's intention is to destroy the League and take over the world. He uncovers Batman's secret contingency plans, which the caped crusader had developed to incapacitate his fellow superheroes should any of them go rogue. These dossiers outline each member's strength and weakness with detailed methods to neutralize them if necessary. The tactic cautions discretion, as the plans were never meant to be employed recklessly. Unfortunately, Savage adapts these blueprints to exploit the vulnerabilities of the heroes with fatal intent.

As the villains commence their calculated attacks, the Justice League members—Superman, Batman, Wonder Woman, The Flash, Green Lantern, Martian Manhunter, and Cyborg—find themselves targeted and systematically taken down. Their strengths are turned into weaknesses, and they are forced to deal with their own personalized threats. While confronting their adversaries, the heroes grapple with the realization that their secrets and safety measures have been compromised. The trust within the team is shaken, particularly towards Batman, as they must regroup and uncover the mastermind behind the assault. The Justice League endeavors to turn the tide against this unprecedented coordinated strike, racing against time to thwart the plans that were originally designed for their protection, now weaponized against them.